解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The mechanisms by which intercurrent bacterial infections are associated with increased tissue injury in some forms of glomerulonephritis may include complement activation by bacteria and subsequent increased glomerular neutrophil (PMN) infiltration. We have studied the effect of complement activation after cobra veno...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185578
更新日期:1989-01-01 00:00:00
abstract::Medullary sponge kidney was found in association with congenital absence of teeth (anodontia) in 3 siblings of a single family. Anodontia occurs in the rare familial syndrome of ectodermal dysplasia, but its association with a renal (mesodermal) anomaly is not known. The present report lends further support to a possi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184918
更新日期:1988-01-01 00:00:00
abstract::Nonspecific symptoms are common in dialysis patients but few methods are available to measure their severity and their response to alteration in dialysis therapy. To determine the clinical features and measure the severity of the most important symptoms in end-stage renal disease (ESRD) patients, 97 dialysis patients ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185141
更新日期:1988-01-01 00:00:00
abstract::A 5-year-old Chinese girl had had absence seizures and received sodium valproate (VPA) treatment which provided good control. Six months later, she developed interstitial nephritis with proteinuria and microhematuria. Renal biopsy revealed interstitial nephritis with granular deposition of immunoglobulin G (IgG) and C...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184867
更新日期:1988-01-01 00:00:00
abstract::Gentamicin doses of 40 mg/kg body weight/day were administered intravenously to 62 Wistar rats. Nineteen animals were also treated orally with an NaHCO3 solution in place of water. The gentamicin-treated animals showed increased albuminuria immediately after the 3rd day of treatment. The fact that this increase was ma...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185043
更新日期:1988-01-01 00:00:00
abstract::Clearance and in vitro microperfusion studies were performed in rabbits to determine the effect of cisplatin on proximal straight tubule transport of calcium and magnesium. Rabbits were injected with cisplatin (2.5 mg/kg i.p. once weekly) for 3 weeks, whereas control rabbits received normal saline solution which serve...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184988
更新日期:1988-01-01 00:00:00
abstract::The variations of ionized and total calcium concentrations were studied during haemodialysis with high flux membrane using dialysate calcium concentrations of 1.63 and 1.76 mmol/l. The changes in ionized and total calcium were related to the predialytic calcium concentration difference between plasma and dialysate. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184951
更新日期:1988-01-01 00:00:00
abstract::A prospective study evaluated the complications in 154 patients in whom a permanent peritoneal dialysis catheter was inserted percutaneously from April 1982 to June 1986. Obstruction to flow and fluid leakage occurred in 9.2 and 2.6% of the catheters, respectively. Catheter survival was 64.6 and 48.6% at 1- and 2-year...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184860
更新日期:1988-01-01 00:00:00
abstract::To probe renal hemodynamic measurements in relation to simultaneous systemic hemodynamic measurements in normal, adult, conscious dogs on a magnesium-deficient diet, 6 experimental animals were given 4 weeks of a magnesium-deficient diet compared to 9 animals whose dietary magnesium was normal. Systemic hemodynamics w...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185169
更新日期:1988-01-01 00:00:00
abstract::A low-protein, low-phosphorus diet supplemented with essential amino acids and keto analogues was given to 12 rats, starting from the 90th day after subtotal nephrectomy. The purpose was to assess its effect on the residual renal function and on the nutritional status in rats with already established severe renal fail...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185055
更新日期:1988-01-01 00:00:00
abstract::Experiments were conducted which revealed the renal transport mechanism(s) of oxypurines by employing uricosuric agents and pyrazinamide. All specimens being drawn from healthy, normal subjects, the data showed that probenecid increased fractional uric acid, fractional hypoxanthine and fractional xanthine clearance, 3...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184888
更新日期:1988-01-01 00:00:00
abstract::IgA nephropathy besides exhibiting a characteristic geographical distribution has been noted to have a low incidence in the blacks of the USA. There is a paucity of data on IgA nephropathy in the blacks of Africa. We report our findings among the blacks and compare these with Indians. An analysis of the primary glomer...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185144
更新日期:1988-01-01 00:00:00
abstract::Atrial natriuretic peptide (ANP) and arginine vasopressin concentrations were measured in 9 patients with pregnancy-induced hypertension. The results were compared to those found in 7 normal pregnant women matched for age, duration of pregnancy, and parity. Plasma ANP levels were significantly higher in the pregnancy-...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185040
更新日期:1988-01-01 00:00:00
abstract::The effect of imidazole-2-hydroxibenzoate on urinary excretion rates of glycosaminoglycans and albumin in 22 insulin-dependent diabetics with albumin excretion rates under 300 mg/day was evaluated in a 165-day double blind crossover study. Unlike placebo, the drug reduced glycosaminoglycan and albumin excretion rates ...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000185115
更新日期:1988-01-01 00:00:00
abstract::A long-term hemodialysis male patient was known to have systemic iron overload due to regular blood transfusions. As he was suspected to have aluminum overload, he received a single intravenous administration of desferrioxamine (that supported the hypothesis). Four days later, he became highly febrile with no focus of...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185208
更新日期:1988-01-01 00:00:00
abstract::Fifteen patients with advanced renal failure (creatinine clearance less than 25 ml/mn) and with severe albuminuria (greater than 1.5 g/24 h) were put on a low-protein (0.3 g/kg body weight), low-phosphorus (5-7 mg/kg body weight) diet supplemented with essential amino acids and ketoanalogues. During the 6-month follow...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185189
更新日期:1988-01-01 00:00:00
abstract::The capacity of peripheral blood mononuclear cells (PBMC) to undergo spontaneous and induced interleukin-1 (IL-1) production was examined in 10 healthy controls and in 10 patients undergoing intermittent hemodialysis (HD) using cuprophane membranes. Extracellular and cytoplasmic IL-1 activity was assayed by biologic a...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185187
更新日期:1988-01-01 00:00:00
abstract::Previous studies of IgA nephropathy have demonstrated a number of prognostically significant clinical and pathological factors in groups of patients with the full histological spectrum of the disease. Whether these factors can be applied to a group of IgA nephropathy patients with disease of moderate degree is unknown...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184518
更新日期:1987-01-01 00:00:00
abstract::To explain the occurrence of tubular and glomerular proteinuria in patients with primarily tubular or glomerular dysfunction, it is usually assumed that the mechanisms responsible for the renal tubular transport of small and large proteins are different. The present in vivo study does not support this hypothesis since...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184090
更新日期:1987-01-01 00:00:00
abstract::The frequency of thrombocytopenia in patients with chronic renal failure (CRF) is controversial. This study was undertaken to investigate the platelet count in 55 patients with end-stage renal disease on maintenance hemodialysis and in 19 patients with CRF before hemodialysis had begun. In both groups platelet counts ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184118
更新日期:1987-01-01 00:00:00
abstract::In 92 renal transplant recipients, serum or plasma levels of neopterin were significantly elevated during pretransplant uremia, rejection, cyclosporin A induced nephrotoxicity and cytomegalovirus (CMV) infections. In patients with normal serum creatinine (less than 115 mumol/l) 71% had elevated serum neopterin levels....
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184375
更新日期:1987-01-01 00:00:00
abstract::Fifty-eight previously untreated adults with minimal-change nephrotic syndrome (MCNS), who had a mean follow-up period of 35.8 months, were studied with regard to their response to alternate-day steroid therapy. The nephrotic syndrome in 54 patients (93%) remitted by 12 weeks and patients continued to be in remission ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184494
更新日期:1987-01-01 00:00:00
abstract::We followed renal function through the natriuretic phase of 6 occasions of drug-induced recovery from minimal lesions nephrotic syndrome (MLNS). Protein excretion started to fall 1-3 days prior to the start of the natriuresis. The natriuresis was accompanied by a rise in glomerular filtration rate (GFR, inulin clearan...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184486
更新日期:1987-01-01 00:00:00
abstract::The techniques of bonding of anionic antibiotics by treatment with cationic surfactants were applied to continuous ambulatory peritoneal dialysis (CAPD) catheters. The elution of 14C-penicillin from tridodecylmethylammonium chloride (TDMAC) treated silicone elastomer catheters in dialysis solution was biphasic, with 9...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184366
更新日期:1987-01-01 00:00:00
abstract::During chronic chlorthalidone treatment of patients with essential hypertension, distal tubular sodium reabsorption is continuously inhibited. At the same time, sodium balance is maintained by an increase of the proximal tubular sodium reabsorption. In the present study, we investigated whether this increase is caused...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184485
更新日期:1987-01-01 00:00:00
abstract::Plasma levels of granulocyte lactoferrin, granulocyte myeloperoxidase and granulocyte elastase in complex with alpha 1-proteinase inhibitor were investigated during hemodialysis in oliguric patients following cadaveric renal transplantation (CRT). The results were compared with those of patients undergoing regular hem...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184333
更新日期:1987-01-01 00:00:00
abstract::The effect of the antiplatelet agents, ticlopidine and dipyridamole, on nephrotoxic serum nephritis (NTN) was evaluated in rats. An accelerated form of NTN was induced with preimmunization of rabbit IgG 7 days before injection of rabbit antirat nephrotoxic serum. Twelve animals received a peroral dose of 20 mg of ticl...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184169
更新日期:1987-01-01 00:00:00
abstract::The effect of uremia upon the hepatic clearance rate of prednisone was studied in isolated perfused livers of normal and uremic female rats. The perfusion rate was kept at a constant flow rate of 25 ml/min. In order to induce uremia, one group of rats was 5/6 nephrectomized 3 weeks prior to the perfusions. The concent...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184072
更新日期:1987-01-01 00:00:00
abstract::The effects of dietary protein both before and after uranyl-nitrate-induced acute renal failure were investigated. Male Sprague-Dawley rats were maintained on high-protein (60%), normal-protein (20%), low-protein (5%) and no-protein diets for 8 days prior to intravenous administration of uranyl nitrate (10 mg/kg). Imm...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184167
更新日期:1987-01-01 00:00:00
abstract::An 11-year-old boy developed Kaposi's sarcoma and progressive T lymphocyte deficiency 5 years after cadaveric kidney transplantation for end-stage renal disease. He had received 17 individual red blood cell transfusions prior to and during transplantation in 1980. Human immunodeficiency virus (HIV) was cultured from b...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184458
更新日期:1987-01-01 00:00:00
abstract::A patient with cadaveric renal transplantation was diagnosed by brain-computed tomography and ELISA as having neurocysticercosis in the CSF. Complete cure was achieved after praziquantel therapy. Function of the allograft was not affected. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184074
更新日期:1987-01-01 00:00:00
abstract::Most hypertensive subjects are overweight, and as a consequence have an increased prevalence of hypercholesterolaemia, impaired glucose tolerance, and left ventricular hypertrophy. Reduction of the blood pressure by antihypertensive drugs without control of the obesity leaves these additional risk factors for cardiova...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184543
更新日期:1987-01-01 00:00:00
abstract::The recent experience of six large trials of antihypertensive therapy has not clearly demonstrated any beneficial effect on the prevention of coronary heart disease (CHD). The data from the HDFP study have been analyzed by three cholesterol strata at baseline. The higher the baseline cholesterol levels, the greater th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184564
更新日期:1987-01-01 00:00:00
abstract::We have evaluated the effect of the antihyperlipidemic agent probucol on hyperlipidemia in patients with nephrotic syndrome. Twelve patients with long-standing nephrotic syndrome received 500 mg of probucol daily for 12 weeks. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol were significantl...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184524
更新日期:1987-01-01 00:00:00
abstract::This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver ce...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184292
更新日期:1987-01-01 00:00:00
abstract::HLA antigens of Japanese patients with primary glomerulopathies were determined, and the frequency of each HLA antigen was compared with that of Japanese normal controls. IgA nephropathy with HLA-DR4, idiopathic membraneous glomerulopathy with DR2, lipoid nephrosis with DRw53 and poststreptococcal glomerulonephritis w...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184089
更新日期:1987-01-01 00:00:00
abstract::The clinicopathological findings of isolated mesangial C3d deposition in the absence of other complement components or immunoglobulins are summarized. 55 out of 242 individual human renal biopsies examined by immunoperoxidase microscopy had isolated C3d deposition. This group consisted of 12 patients with chronic glom...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184339
更新日期:1987-01-01 00:00:00
abstract::Pulmonary calcifications are known to occur in patients with chronic renal failure. Recently, scintigrams with bone-seeking radionuclides have been used to detect subclinical pulmonary calcium deposits. We studied 18 children on maintenance dialysis without evidence of pulmonary calcification on chest X-ray. Four chil...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183911
更新日期:1986-01-01 00:00:00
abstract::To test the hypothesis that acute angiotensin-converting enzyme (ACE) inhibition might predict the postoperative blood pressure outcome, a single oral dose of captopril ranging from 12.5 to 100 mg, was given to 26 patients with renovascular disease and its hypotensive effect was compared with that of surgery (21 patie...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184054
更新日期:1986-01-01 00:00:00
abstract::A retrospective analysis of renal vein renin results has been done in 96 patients with renal artery stenosis and hypertension studied in two Italian centers (Sassari and Pisa) with respect to the outcome of either surgery or percutaneous transluminal angioplasty (PTA). In all patients the renal vein renin ratio and th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184039
更新日期:1986-01-01 00:00:00